Histopathologic examination creates a better understanding of the manifestations of diseases in the ears.
Microscopic studies of a range of otic structures, such as the tympanic membrane, middle ear, and inner ear reveal changes that occur from medications to treat auditory dysfunction, and from toxicity of drugs and chemicals.
Turner Scientific harvests, processes, embeds, sections, and stains slides and the experienced veterinary histopathologists at Greenfield Pathology Services (GPS) assess the slides.
General pathology capabilities through include histopathologic evaluation of the inner, middle, and external ear for multiple species in support of GLP and non-GLP toxicology studies:
- Sections of external and middle ear are processed and stained with hematoxylin and eosin following routine procedures to allow evaluation of multiple structures within these complex 3-dimensional structures. Assessment of external and middle ear spaces are especially helpful for treatments administered locally to the external or middle ear.
- Inner ears (cochlea and sometimes vestibular structures) are processed, step sectioned, and stained with hematoxylin and eosin. Cochleas are oriented to capture mid-modiolar sections to allow for detailed examination of all parts of the inner ear.