JARED HARTSOCK

Education/Training

M.Sc. 2012, Speech and Hearing Sciences, Washington University in St. Louis, St. Louis, MO

B.S. 2004, Biology, Illinois College, B.S. 2004, Biology

Positions

Senior Research Technician (2013-present)- Department of Otolaryngology Washington University School of Medicine, St. Louis, MO 63110

Research Assistant (2005-2012)- Department of Otolaryngology Washington University School of Medicine, St. Louis, MO 63110

Admission Counselor (2004-2005)- Department of Admission Illinois College, Jacksonville, IL 62650

Undergraduate Research Assistant (2002-2004)- Department of Biology Illinois College, Jacksonville, IL 62650

 

Research Publications

Salt A, Hartsock J, Gill R, Smyth D, Kirk J, Verhoeven K. Perilymph pharmacokinetics

of marker applied through a cochlear implant in guinea pigs. PLoS One. 2017 12(8):e0183374

 

 Li, W, Hartsock JJ, Dai C, Salt AN. Permeation Enhancers for Intratympanically-Applied Drugs studied using Fluorescent Dexamethasone as a Marker. Otology & Neurotology (in review)

 

 Salt AN, Hartsock JJ, Gill RM, King E, Kraus FB, Plontke SK. Perilymph pharmacokinetics of locally-applied gentamicin in the guinea pig. Hear Res. 2016 342:101-111.

 

Lichtenhan JT, Hartsock J, Dornhoffer JR, Donovan KM, Salt AN. Drug delivery into the cochlear apex: Improved control to sequentially affect finely spaced regions along the entire length of the cochlear spiral. J Neurosci Methods. 2016 , 273:201-209.

 

Plontke SK, Hartsock JJ, Gill RM, Salt AN Intracochlear drug injections through the round window membrane: Measures to improve drug retention. Audiol Neurootol. 2016;21:72-79.

 

Salt AN, Gill RM, Hartsock JJ. Perilymph Kinetics of FITC-Dextran Reveals Homeostasis Dominated by the Cochlear Aqueduct and Cerebrospinal Fluid. J Assoc Res Otolaryngol. 2015;16:357-371.

 

Hirose K, Hartsock JJ, Johnson S, Santi P, Salt AN. Systemic lipopolysaccharide compromises the blood-labyrinth barrier and increases entry of serum fluorescein into the perilymph. J Assoc Res Otolaryngol. 2014 15:707-719.

 

Lichtenhan JT, Hartsock JJ, Gill RM, Guinan JJ Jr, Salt AN.The auditory nerve overlapped waveform (ANOW) originates in the cochlear apex. J Assoc Res Otolaryngol. 2014 Jun;15(3):395-411.

 

King EB, O’Leary SJ, Hartsock JJ, Salt AN. Influence of Cochleostomy and Cochlear Implant Insertion on Drug Gradients following Intratympanic Application in Guinea Pigs. Audiol Neurootol. 2013; 18:307-316.

Salt AN, Lichtenhan JT, Gill RM, Hartsock JJ. Large endolymphatic potentials from low-frequency and infrasonic tones in the guinea pig. J Acoust Soc Am. 2013 133 :1561-1571

 

Salt AN, Hartsock JJ, Gill RM, Piu F, Plontke SK. Perilymph pharmacokinetics of markers and dexamethasone applied and sampled at the lateral semi-circular canal. J Assoc Res Otolaryngol. 2012 13(6): 771–783.

 

Hahn H, Salt AN, Beigner, T, Kammerer B, Delabar U, Hartsock J, Plontke SK. Dexamethasone levels and base to apex concentration gradients in scala tympani perilymph following intracochlear delivery in the guinea pig Otol Neurotol. 33:660-665, 2012.

 

Salt AN, King EB, Hartsock JJ, Gill RM, O'Leary SJ. Marker entry into vestibular perilymph via the stapes following applications to the round window niche of guinea pigs. Hear Res. 2012 283:14-23.

 

Salt AN, Hartsock  JJ, Plontke SK, LeBel C, Piu F. Distribution of dexamethasone and preservation of inner ear function following intratympanic delivery of a gel-based formulation. Audiology & Neurotology 2011; 16:323-335.

 

Brown DJ, Hartsock JJ, Gill RM, Henson H, Salt AN. Estimating the operating point of the cochlear transducer using low-frequency biased distortion products. J Acoust Soc Am. 2009 125:2129-2145.

 

Mikulec AA, Plontke SK, Hartsock JJ, Salt AN Entry of substances into perilymph through the bone of the otic capsule following intratympanic applications in guinea pigs: Implications for local drug delivery in humans. Otol Neurotol. 30:131-138, 2009.

 

Salt AN, Brown DJ, Hartsock JJ, Plontke SK. Displacements of the organ of Corti by gel injections into the cochlear apex. Hear Res. 2009 250:63-75.

 

Mikulec AA, Hartsock JJ, Salt AN. Permeability of the round window membrane is influenced by the composition of applied drug solutions and by common surgical procedures, Otol Neurotol 29:1020-1026, 2008.

 

Salt, A.N., Sirjani, D.B., Hartsock, J.J.,  Gill, R.M., Plontke, S.K. Marker  Retention in the Cochlea Following Injections through the Round Window Membrane. Hear Res. 2007; 232:78-86.

 

Zettler, LW, KA Piskin, SL Stewart, JJ Hartsock, ML Bowles, and T Bell.   

Protocorm mycobiants of a Federally threatened orchid, Platanthera leucophaea, and a technique to promote leaf formation in seedlings. Studies in Mycology 53: 163-171.

Zettler, LW, KA Piskin, SL Stewart, JJ Hartsock, and SL Stewart. Symbiotic

Seed germination of North American species of Cyrtopodium, Piperia, Platanthera, and Spiranthes (Orchidaceae) with single mycobiont.

           

Abstracts

Li W, Hartsock J, Dai C, Salt A. Permeation Enhancers for Intratympanically-applied

Drugs Studied Using Fluorescent Dexamethasone as a Marker. 40th Midwinter Research Meeting of the ARO, Baltimore, Feb 2017, PS817.

 

Salt A, Hartsock J, Smyth D, Kirk J, Verhoeven K. Drug Delivery Through a Cochlear Implant in Guinea Pigs for up to 7 Days: Pharmacokinetic, Functional and Morphologic Evaluation. 40th Midwinter Research Meeting of the ARO, Baltimore, Feb 2017, PS812.

 

Salt A, Hartsock J, Smyth D, Verhoeven K. Pharmacokinetics of Drugs Delivered by a Cochlear Implant with Cannula in Guinea Pigs. Midwinter Research Meeting of the ARO, San Diego, Feb 2016, p212.

 

Hirose K, Hartsock J, Salt A Cochlear inflammation and the dynamic blood-perilymph barrier. 39th Midwinter Research Meeting of the ARO, San Diego, Feb 2016, p132.

 

Salt A, Hartsock J, Gill R, Kraus F, King E, Plontke S. Gentamicin Distribution in the

Ear Following Local Applications. 39th Midwinter Research Meeting of the ARO, San Diego, Feb 2016, p78.

 

Hirose K, Hartsock J, Salt A. The Blood-Labyrinth Barrier and its Influence on

Endocochlear Potential. 39th Midwinter Research Meeting of the ARO, Baltimore, Feb 2015, p346.

 

Hirose K, Hartsock J, Johnson S, Santi P, Salt A Systemic Endotoxin Enhances Entry of Fluorescein Into Perilymph Through Compromise of the Blood-Labyrinth Barrier. 37th Midwinter Research Meeting of the ARO, San Diego, Feb 2014, p503.

 

Salt AN, Hartsock J, Gill R; Piu F, Plontke S Manipulations of Dexamethasone Kinetics in Perilymph. 37th Midwinter Research Meeting of the ARO, San Diego, Feb 2014 p 467.

 

Salt AN, Hartsock JJ, Gill RM Pharmacokinetics of perilymph assessed with fluorescent markers. 36th Midwinter Research Meeting of the ARO, Baltimore, Feb 2013. 

 

Salt AN, Piu, F, Hartsock, JJ, Gill RM, Plontke SK. Dexamethasone pharmacokinetics   

in the inner ear assessed by injection and sampling at the lateral semi-circular canal. 35th Midwinter Research Meeting of the ARO, San Diego, Feb 2012

  

Hartsock JJ, Thomas EB, Bretan PM, Gill RM, O’Leary SJ, Salt AN. Substances Enter Perilymph Near the Stapes as well as through the Round Window

Membrane following Intratympanic Applications in Guinea Pigs. 34th Midwinter Research Meeting of the ARO, Baltimore, MD, 2011.

 

Salt AN, Hartsock JJ, Bretan PM, Gill RM.  Evaluation of a Ten-Compartment Computer Model of the Inner Ear Fluid Spaces. 34th Midwinter Research Meeting of the ARO, Balitmore, MD, 2011.

 

Hartsock JJ, Gill RM, Salt AN. Sequential sampling of perilymph from the lateral semi-circular canal. 33rd Midwinter Research Meeting of the ARO, Anaheim, CA, 2010.

 

Salt AN, Gill RM, Hartsock JJ. Infrasound-induced cochlear microphonics in scala media include a component from non hair-cell sources. 33rd Midwinter Research Meeting of the ARO, Anaheim, CA, 2010.

 

Salt AN, Hartsock JJ. Cochlear drug gradients and functional changes with sustained intratympanic dexamethasone delivery. Prosper Meniere Society, Austria 2010.

 

Salt AN Hartsock JJ. Perilymph pharmacokinetics in the guinea pig inner ear compared for local injections at different sites. 32nd Midwinter Research Meeting of the ARO, Baltimore, 2009.

 

Brown DJ, Hartsock JJ, Plontke SK,  Salt AN. Prolonged basilar membrane displacements during gel injections into the cochlear apex and increased sensitivity to infrasound following the injections. 32nd Midwinter Research Meeting of the ARO, Baltimore, 2009.

 

Salt AN, Hartsock JJ, Gill RM Functional Changes Associated with "One-Shot"   Intracochlear Injections through the Round Window Membrane. 31st Midwinter Research Meeting of the ARO, 2008.

 

Mikulec AA, Plontke SK, Hartsock JJ, Salt AN. Drugs Enter the Perilymph of Guinea Pigs through the Bony Otic Capsule. 31st Midwinter Research Meeting of the ARO, 2008.

 

Salt, A.N., Hartsock, J.J., Sirjani, D.B., Plontke, S.K. Perilymph pharmacokinetics following one-shot injections into the basal cochlear turn of guinea pigs. 30th Midwinter Research Meeting of the ARO, 2007.

 

Hartsock, JJ, Piskin KA, and Zettler LW. 2003. Symbiotic seed germination of two Showy terrestrial orchids ( Platanthera ciliaris, P. cristata; Orchidaceae) using Mycorrhizal fungi. Southeastern Biology 50(2): 149.

Piskin, KA, Hartsock JJ,  Zettler LW, and Bowles ML. 2003. Seed germination Requirements of a Federally threatened orchid (Platanthera leucophaea) in nature, and a technique to establish leaf-bearing seedlings onto soil. Southeastern Biology 50(2): 170.

 

Hartsock, JJ. Symbiotic seed germination of Platanthera ciliaris and P. cristata. Association of Southeastern Biologists, Washington, D.C. 2002.

Piskin, KA, Hartsock JJ,  Zettler LW, and Bowles ML. 2003. Seed germination Requirements of a Federally threatened orchid (Platanthera leucophaea) in nature, and a technique to establish leaf-bearing seedlings onto soil. Southeastern Biology 50(2): 170.

 

Hartsock, JJ. Symbiotic seed germination of Platanthera ciliaris and P. cristata. Association of Southeastern Biologists, Washington, D.C. 2002.

Published Artwork

Zettler, LW, KA Piskin, SL Stewart, JJ Hartsock, ML Bowles, and T Bell.  Protocorm mycobiants of a Federally threatened orchid, Platanthera leucophaea, and a technique to promote leaf formation in seedlings. Studies in Mycology 53: 163-171.