Leonard P. Rybak, M.D., Ph.D.

Dr. Leonard P. Rybak is a Research Professor at the Southern Illinois University School of Medicine, and was a practicing otolaryngologist from 1979-2017. He received his medical degree from the Medical College of Wisconsin-Milwaukee, and completed his residency in otolaryngology and also obtained a PhD at the University of Minnesota-Minneapolis. He served as an assistant professor of otolaryngology at the University of Minnesota prior to his current role at the SIU School of Medicine.

 

Dr. Rybak's professional affiliations include the American College of Surgeons and the American Academy of Otolaryngology - Head and Neck Surgery. Locally, he is a member of the Sangamon County Medical Society and has served on various committees at St. John’s Hospital and the SIU School of Medicine. He has served as president of the Sangamon County Chapter of the Society for Neuroscience.

 

Education 

 

Medical School: Medical College of Wisconsin, Milwaukee, WI

 

Residency: University of Minnesota, Minneapolis, MN - Otolaryngology

Recent Research Funding

Endogenous Modulation of Cochlear Injury. Leonard P. Rybak, MD, PhD, Principal Investigator, National Institutes of Health, National Institute on Deafness and Other Communicative Disorders (R01 DC 02396-18A1, competing renewal, March 1, 2014- February 28, 2019, total direct costs $1,062,500*. Currently funded on a no cost extension until February 29, 2020.

 

Transplatin: A Novel Agent to Mitigate Cisplatin Toxicity. Vickram Ramkumar, Principal Investigator, Leonard P. Rybak, co-investigator, National Cancer Institute, R01 CA 166907-01A1, July 1, 2013-June 30, 2018, total costs $1,500,000*.

 

Phase II Clinical Trials; D-methionine to Reduce Noise-Induced Hearing Loss. Department of Defense Kathleen Campbell PhD, PI, Co-Is Leonard Rybak, MD. PhD Joseph Milbrandt,PhD, Maj Jillyen Mathis AuD, Carrie Redlich, MD, Martin Slade MPH. ($2,568,584.99) March 1, 2011 through Feb 28, 2016*.

Optimizing D-methionine pre-loading and rescue dosing through functional and biomarker measures, Kathleen Campbell, PhD, Principal Investigator, , Leonard Rybak, M.D. Ph.D, coinvestigator, National Institutes of Health, National Institute on Deafness and Other Communicative Disorders, ) 1 R01DC014549-01. April 1, 2015 --March 31, 2020. Total direct costs $1,924,071*.

 

Academic and Professional Honors

 

Paparella Lecturer and Award Recipient, University of Minnesota Department of Otolaryngology, May 4, 2015

Distinguished Research Award, Southern Illinois University School of Medicine, Department of Surgery; 2009

Recent Publications

Peer Reviewed Journal Articles

 

Jiang P, Ray A, Rybak LP Brenner M: Role of STAT1 and Oxidative Stress in GentamicinInduced Hair Cell Death in Organ of Corti, Otol Neurotol: October 2016 - Volume 37 - Issue 9 - p 1449–1456.

Kaur T, Borse V, Sheth S, Sheehan K, Ghosh S, Tupal S, Jajoo S, Mukherjea D, Rybak L P, Ramkumar V.: Adenosine A1 Receptor Protects Against Cisplatin Ototoxicity by Suppressing the NOX3/STAT1 Inflammatory Pathway in the Cochlea. J Neurosci 36:3962- 3977, 2016.

Fox DJ, Cooper MD, Speil CA, Roberts MH, Yanik SC, Meech RP, Hargrove TL, Verhulst SJ, Rybak LP, Campbell KCM. D-Methionine Reduces Tobramycin-induced Ototoxicity without Antimicrobial Interference in Animal Models. Journal of Cystic Fibrosis 2015, Jul 9. pii: S1569-1993(15)00158-7. doi: 10.1016/j.jcf.2015.06.005.

Borse V, Al Aameri RFH, Sheehan K, Sheth S, Kaur T, Mukherjea D, Tupal S, Lowy M, Ghosh S, Dhukhwa A, Bhatta P, Rybak LP, Ramkumar V. Epigallocatechin-3-gallate, a prototypic chemopreventative agent for protection against cisplatin-based ototoxicity. Cell Death Dis. 2017 Jul 13;8(7):e2921. doi: 10.1038/cddis.2017.314.

 

Sheth S, Mukherjea D, Rybak LP, Ramkumar V. Mechanisms of cisplatin ototoxicity and Otoprotection. Front Cell Neurosci. 2017 Oct 27;11:338. doi: 10.3389/fncel.2017.00338. e Collection Review.

Sheehan K, Sheth S, Mukherjea D, Rybak LP, Ramkumar V. Trans-Tympanic Drug Delivery for the treatment of ototoxicity. J Vis Exp. 2018 Mar 16;(133). doi: 10.3791/56564.

Ghosh S, Sheth S, Sheehan K, Mukherjea D, Dhukhwa A, Borse V, Rybak LP, Ramkumar V. The Endocannabinoid/cannabinoid 2 receptor system protects against cisplatin induced hearing loss. Front Cell Neurosci. 2018 Aug 21;12:271. doi: 10.3389/fncel.2018.00271 eCollection 2018.

Bhatta P, Dhukhwa A, Sheehan K, Al Aameri RFH, Borse V, Ghosh S, Sheth S, Mamillapalli C, Rybak L, Ramkumar V, Mukherjea D. Capsaicin protects against cisplatin ototoxicity by changing the STAT3/STAT1 ratio and activating cannabinoid (CB2) receptors in the cochlea. Sci Rep. 2019 Mar 11;9(1):4131. doi: 10.1038/s41598-019-40425-9.

Rybak LP, Mukherjea D, Ramkumar V. Mechanisms of cisplatin-induced ototoxicity and prevention. Semin Hear. 2019 May;40(2):197-204. doi: 10.1055/s-0039-1684048. Epub 2019 Apr 26. Invited Review.

Books and/or Chapters (Author)

Monsell, EM, Cass, S, Rybak, LP, Nedzelski, JM: Chemical Treatment of the Labyrinth, In: D.E. Brackman, C. Shelton, and M. Arriaga (eds), Otologic Surgery, Fourth edition, Elsevier, Philadelphia, pp. 431-444, 2016.

Ramkumar V, Borse V, Ghosh S, Kaur T, Sheehan, K, Sheth S, Dhukhwa A, Tupal S, Mukherjea D, Rybak LP: Role of Adenosine Receptors in Auditory Functions, Chapter 9 in: Adenosine Signaling Mechanisms: Pharmacology, Functions and Therapeutic Aspects, Nova science publishers, pages 183-192, 06/2015.

Rybak, L.P. and Brenner MJ: Vestibular and Auditory Toxicity, In: Cummings C.W. et al. (eds), Otolaryngology: Head and Neck Surgery, Sixth Edition, Elsevier Saunders: Philadelphia, Vol. 3, pp. 2369-2382, 2015.

Rybak, LP. The Cochlea, chapter in Ramkumar V and Rybak LP (editors) Inflammatory Mechanisms in Mediating Hearing Loss. Springer International Publishing Company AG, part of Springer Nature, 2018, Cham, Switzerland.

Sheth S, Mukherjea D, Rybak, LP, Ramkumar V. The Contribution of Anti-oxidant and Antiinflammatory Functions of Adenosine A1 Receptor in Mediating Otoprotection. Chapter in Ramkumar V and Rybak LP (editors) Inflammatory Mechanisms in Mediating Hearing Loss. Springer International Publishing Company AG, part of Springer Nature, 2018, Cham, Switzerland.

Books (Editor)

Miller J, Le Prell, C and Rybak, L (editors). Free Radicals in ENT Pathology, Springer, New York, NY, 2015.

Ramkumar V and Rybak LP (editors) Inflammatory Mechanisms in Mediating Hearing Loss. Springer International Publishing Company AG, part of Springer Nature, 2018, Cham, Switzerland.