May 16, 2019

“Normal” hearing at any frequency in humans is defined as the ability to perceive a sound at a
volume of 20 dB or less. Hearing loss is not considered to be “severe” until the volume required
to perceive a sound reaches a threshold of 70 dB, and “profound” hearing loss...

May 16, 2019

It is well known among auditory scientists and clinicians that hearing loss from any cause,
including ototoxicity, has substantial psychosocial consequences on adults, such as
communication difficulties, social isolation, social stigmatization, cognitive impairment, lo...

May 6, 2019

Few members of the pharmacology and biotechnology communities would deny that hearing is
generally important. However, when considering the necessity for ototoxicity screening and
prevention, many drug developers and regulatory experts assume that only severe

March 11, 2019

Nonsteroidal anti-inflammatory drugs (NSAIDs) and acetaminophen are the two most
commonly used medications, with up to 24% of adults taking ibuprofen (an NSAID) and 28%
taking acetaminophen in any week (Kyle et al., 2015). Salicylate, the active ingredient in aspirin,

March 8, 2019

The effect that tinnitus has on quality of life is quite variable. This is largely due to the diversity
of tinnitus presentations: it can be acute or chronic, constant or intermittent, subtle or intense.
The impact on tinnitus sufferers is therefore correlated with eac...

March 5, 2019

Many pharmacologic treatments have been suggested for tinnitus, but most claims of
effectiveness do not withstand scientific evaluation or meta-analysis (Hesse, 2016). Multiple
non-pharmacologic therapies are either currently available or are being developed for tinnit...

March 5, 2019

"I have severe hearing damage. It's manifested itself as tinnitus, ringing in the ears at
frequencies that I play guitar. It hurts, it's painful, and it's frustrating"– Pete Townsend

It is not surprising that playing guitar for The Who over many years is a risk factor...

December 11, 2018

One of the authors (DH) of this blog article has a confession to make: I don’t like cheese. In fact,
I hate it, and always have. I don’t know why, but there is no type of cheese that I find tolerable.
So, when I recently heard that a nutrient found in several types of...

December 11, 2018

Phosphodiesterase type 5 (PDE-5) inhibitors are a class of drugs that reduce the degradation of nitric oxide (NO) activated cyclic guanosine monophosphate (cGMP), and thereby promote relaxation of smooth muscles in blood vessels and increased blood flow (Maddox et al.,...

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